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FAMILIAL MEDITERRANEAN FEVER
Health & Medicine Week
June 9, 2008
Research in the area of familial mediterranean fever reported from
T.K. Davtyan and colleagues
"Familial Mediterranean fever (FMF) is a relapsing autoinflammatory
disorder, caused by various mutations in the MEFV gene, which encodes
a protein called pyrin, expressed in neutrophils and activated
monocytes. Induction of monocyte endotoxin tolerance is observed in
FMF patients during attack, whereas monocytes from patients in the
attack-free period failed to induce lipopolysaccharide tolerance and
exhibited heightened sensitivity to bacterial endotoxin," scientists
in Yerevan, Armenia report (see also Familial Mediterranean Fever).
"In this study, we demonstrated that impaired lipopolysaccharide
tolerance induction in attack-free FMF patients correlates with
both increased lipopolysaccharide-induced proinflammatory cytokine
synthesis polarization and a different time-course pattern of
lipopolysaccharide-induced changes on monocytic surface expression
of CD14 and CD11b coreceptors. We found that this pattern is
characterized either by delayed turnover of CD14 or increased surface
retention of CD11b receptors on monocytes during stimulation with
lipopolysaccharide," wrote T.K. Davtyan and colleagues.
The researchers concluded: "In addition, enhancement of
lipopolysaccharide-induced apoptosis of neutrophils was observed in
FMF patients, and was confirmed based on the fact that neutrophils from
FMF patients previously unexposed to Salmonella enteritidis exhibited
heightened susceptibility to the lipopolysaccharide of this pathogen
similar to that of patients infected with this species."
Davtyan and colleagues published their study in Fems Immunology and
Medical Microbiology (Heightened endotoxin susceptibility of monocytes
and neutrophils during familial Mediterranean fever. Fems Immunology
and Medical Microbiology, 2008;52(3):370-378).
For more information, contact T.K. Davtyan, CJSC Armenicum, Armenicum
Research Center, Laboratory Immunology & Virology, 37 Nalbandyan Str,
Yerevan 0001, Armenia.
Publisher contact information for the journal Fems Immunology and
Medical Microbiology is: Blackwell Publishing, 9600 Garsington Rd.,
Oxford OX4 2DQ, Oxon, England.
Keywords: Armenia, Yerevan, Apoptosis, Familial Mediterranean Fever,
Immunology, Rheumatology.
Health & Medicine Week
June 9, 2008
Research in the area of familial mediterranean fever reported from
T.K. Davtyan and colleagues
"Familial Mediterranean fever (FMF) is a relapsing autoinflammatory
disorder, caused by various mutations in the MEFV gene, which encodes
a protein called pyrin, expressed in neutrophils and activated
monocytes. Induction of monocyte endotoxin tolerance is observed in
FMF patients during attack, whereas monocytes from patients in the
attack-free period failed to induce lipopolysaccharide tolerance and
exhibited heightened sensitivity to bacterial endotoxin," scientists
in Yerevan, Armenia report (see also Familial Mediterranean Fever).
"In this study, we demonstrated that impaired lipopolysaccharide
tolerance induction in attack-free FMF patients correlates with
both increased lipopolysaccharide-induced proinflammatory cytokine
synthesis polarization and a different time-course pattern of
lipopolysaccharide-induced changes on monocytic surface expression
of CD14 and CD11b coreceptors. We found that this pattern is
characterized either by delayed turnover of CD14 or increased surface
retention of CD11b receptors on monocytes during stimulation with
lipopolysaccharide," wrote T.K. Davtyan and colleagues.
The researchers concluded: "In addition, enhancement of
lipopolysaccharide-induced apoptosis of neutrophils was observed in
FMF patients, and was confirmed based on the fact that neutrophils from
FMF patients previously unexposed to Salmonella enteritidis exhibited
heightened susceptibility to the lipopolysaccharide of this pathogen
similar to that of patients infected with this species."
Davtyan and colleagues published their study in Fems Immunology and
Medical Microbiology (Heightened endotoxin susceptibility of monocytes
and neutrophils during familial Mediterranean fever. Fems Immunology
and Medical Microbiology, 2008;52(3):370-378).
For more information, contact T.K. Davtyan, CJSC Armenicum, Armenicum
Research Center, Laboratory Immunology & Virology, 37 Nalbandyan Str,
Yerevan 0001, Armenia.
Publisher contact information for the journal Fems Immunology and
Medical Microbiology is: Blackwell Publishing, 9600 Garsington Rd.,
Oxford OX4 2DQ, Oxon, England.
Keywords: Armenia, Yerevan, Apoptosis, Familial Mediterranean Fever,
Immunology, Rheumatology.