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NEW ELAPID VENOMS STUDY FINDINGS RECENTLY WERE PUBLISHED BY A.A. GALOYAN AND CO-RESEARCHERS
Science Letter
December 14, 2010
"We tested the action of proline-rich peptide (PRP-1) and cobra
venom Naja Naja Oxiana (NOX) on Deiters' nucleus neurons at 3rd, 15th
and 35th days after unilateral labyrinthectomy (UL). Early and late
tetanic, post-tetanic potentiation and depression of Deiters'neurons
to bilateral high frequency stimulation of hypothalamic supraoptic
and paraventricualar nuclei was studied," researchers in Yerevan,
Armenia report (see also Elapid Venoms).
"The analysis of spike activity was carried out by mean of on-line
selection and special program. The complex averaged peri-event time and
frequency histograms shows the increase of inhibitory and excitatory
reactions of Deiters' neurons at early stage of vestibular compensation
following PRP-1 and NOX injection, reaching the norm at the end of
tests. In histochemical study the changes in Ca2+-dependent acidic
phosphatase (AP) activity in neurons was discovered. It was shown
that in UL animals the total disappearance or delay of decolorizing
of Deiters' neurons lead to neurodegenerative pattern as cellular
"shade". AP activity after UL and PRP-1 injection exerts more effective
recovery of neurons in comparison with events, observed after the
administration of NOX," wrote A.A. Galoyan and colleagues.
The researchers concluded: "The data of this study indicate that PRP-1
and NOX are protectors, which may successfully recover the disturbed
vestibular functions."
Galoyan and colleagues published their study in Neurochemical Research
(Protective Effects of Hypothalamic Proline-Rich Peptide and Cobra
Venom Naja Naja Oxiana on Dynamics of Vestibular Compensation
Following Unilateral Labyrinthectomy. Neurochemical Research,
2010;35(11):1747-1760).
For additional information, contact V.H. Sarkisian, NAS RA, Orbeli
Institute Physiol, Yerevan, Armenia.
Publisher contact information for the journal Neurochemical Research
is: Springer, Plenum Publishers, 233 Spring St., New York, NY 10013,
USA.
From: A. Papazian
Science Letter
December 14, 2010
"We tested the action of proline-rich peptide (PRP-1) and cobra
venom Naja Naja Oxiana (NOX) on Deiters' nucleus neurons at 3rd, 15th
and 35th days after unilateral labyrinthectomy (UL). Early and late
tetanic, post-tetanic potentiation and depression of Deiters'neurons
to bilateral high frequency stimulation of hypothalamic supraoptic
and paraventricualar nuclei was studied," researchers in Yerevan,
Armenia report (see also Elapid Venoms).
"The analysis of spike activity was carried out by mean of on-line
selection and special program. The complex averaged peri-event time and
frequency histograms shows the increase of inhibitory and excitatory
reactions of Deiters' neurons at early stage of vestibular compensation
following PRP-1 and NOX injection, reaching the norm at the end of
tests. In histochemical study the changes in Ca2+-dependent acidic
phosphatase (AP) activity in neurons was discovered. It was shown
that in UL animals the total disappearance or delay of decolorizing
of Deiters' neurons lead to neurodegenerative pattern as cellular
"shade". AP activity after UL and PRP-1 injection exerts more effective
recovery of neurons in comparison with events, observed after the
administration of NOX," wrote A.A. Galoyan and colleagues.
The researchers concluded: "The data of this study indicate that PRP-1
and NOX are protectors, which may successfully recover the disturbed
vestibular functions."
Galoyan and colleagues published their study in Neurochemical Research
(Protective Effects of Hypothalamic Proline-Rich Peptide and Cobra
Venom Naja Naja Oxiana on Dynamics of Vestibular Compensation
Following Unilateral Labyrinthectomy. Neurochemical Research,
2010;35(11):1747-1760).
For additional information, contact V.H. Sarkisian, NAS RA, Orbeli
Institute Physiol, Yerevan, Armenia.
Publisher contact information for the journal Neurochemical Research
is: Springer, Plenum Publishers, 233 Spring St., New York, NY 10013,
USA.
From: A. Papazian