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REPORTS SUMMARIZE BONE MARROW RESEARCH FROM N.B. TAVAKALYAN AND CO-AUTHORS
Hematology Week
May 31, 2010
Data detailed in 'Influence of unsaturated carbonic acids on
hemocompatibility and cytotoxicity of poly-vinylacetate based
co-polymers' have been presented. According to recent research
published in the Journal of Materials Science Materials In Medicine,
"The aim of this study was to investigate hemocompatibility and
cytotoxicity properties of synthetic polymer coatings containing
various unsaturated carbonic acids with vinylacetate. Co-polymers of
vinylacetate and crotonic acid (CA), maleic acid (MA), and itaconic
acid (IA) were made."
"The materials were characterized in terms of their adhesion to metal
supports (titanium and stainless steel) as well as hemocompatibility (%
hemolysis, wettability, erythrocyte aggregation, hemoglobin content,
thrombocyte count and lipid peroxidation levels) and cytotoxicity
(human endothelial cell activity in vitro and chromosome aberrations,
bone marrow proliferation and cell ploidy in rats).
Co-polymers of unsaturated carbonic acids with vinylacetate exhibited
good hemocompatibility properties, as opposed to vinylacetate
homopolymer for which substantial levels of hemolysis were observed.
By coating the metal supports with co-polymers the cytotoxic effects
associated with the bare metal samples were markedly reduced. MA
samples showed excellent hemocompatibility and no cytotoxicity, yet
they lacked good adhesion properties to metal substrate, probably
due to high water content. CA samples, having the highest density
of carboxylic groups among the samples under investigation, showed
increased bone marrow proliferation activity and cell ploidy in rats,
as compared to controls. The most promising results in the present
study were obtained for the samples with IA, which showed good adhesion
to metal substrates, good hemocompatibility and low cytotoxicity,"
wrote N.B. Tavakalyan and colleagues (see also Bone Marrow).
The researchers concluded: "Thus, co-polymers of vinylacetate and IA
rich in carboxylic groups are promising materials for the design of
novel drug-eluting stents."
Tavakalyan and colleagues published their study in the Journal
of Materials Science Materials In Medicine (Influence of
unsaturated carbonic acids on hemocompatibility and cytotoxicity of
poly-vinylacetate based co-polymers. Journal of Materials Science
Materials In Medicine, 2010;21(5):1693-702).
For additional information, contact N.B. Tavakalyan, Yerevan Institute
Plastpolymer, Arshakunyats Avenue 127, 0007, Yerevan, Armenia.
From: A. Papazian
Hematology Week
May 31, 2010
Data detailed in 'Influence of unsaturated carbonic acids on
hemocompatibility and cytotoxicity of poly-vinylacetate based
co-polymers' have been presented. According to recent research
published in the Journal of Materials Science Materials In Medicine,
"The aim of this study was to investigate hemocompatibility and
cytotoxicity properties of synthetic polymer coatings containing
various unsaturated carbonic acids with vinylacetate. Co-polymers of
vinylacetate and crotonic acid (CA), maleic acid (MA), and itaconic
acid (IA) were made."
"The materials were characterized in terms of their adhesion to metal
supports (titanium and stainless steel) as well as hemocompatibility (%
hemolysis, wettability, erythrocyte aggregation, hemoglobin content,
thrombocyte count and lipid peroxidation levels) and cytotoxicity
(human endothelial cell activity in vitro and chromosome aberrations,
bone marrow proliferation and cell ploidy in rats).
Co-polymers of unsaturated carbonic acids with vinylacetate exhibited
good hemocompatibility properties, as opposed to vinylacetate
homopolymer for which substantial levels of hemolysis were observed.
By coating the metal supports with co-polymers the cytotoxic effects
associated with the bare metal samples were markedly reduced. MA
samples showed excellent hemocompatibility and no cytotoxicity, yet
they lacked good adhesion properties to metal substrate, probably
due to high water content. CA samples, having the highest density
of carboxylic groups among the samples under investigation, showed
increased bone marrow proliferation activity and cell ploidy in rats,
as compared to controls. The most promising results in the present
study were obtained for the samples with IA, which showed good adhesion
to metal substrates, good hemocompatibility and low cytotoxicity,"
wrote N.B. Tavakalyan and colleagues (see also Bone Marrow).
The researchers concluded: "Thus, co-polymers of vinylacetate and IA
rich in carboxylic groups are promising materials for the design of
novel drug-eluting stents."
Tavakalyan and colleagues published their study in the Journal
of Materials Science Materials In Medicine (Influence of
unsaturated carbonic acids on hemocompatibility and cytotoxicity of
poly-vinylacetate based co-polymers. Journal of Materials Science
Materials In Medicine, 2010;21(5):1693-702).
For additional information, contact N.B. Tavakalyan, Yerevan Institute
Plastpolymer, Arshakunyats Avenue 127, 0007, Yerevan, Armenia.
From: A. Papazian