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STUDY FINDINGS FROM INSTITUTE OF MOLECULAR BIOLOGY PROVIDE NEW INSIGHTS INTO NEUROCHEMICAL RESEARCH
Mental Health Weekly Digest
June 14, 2010
Researchers detail in 'Alternative complement pathway in
schizophrenia,' new data in neurochemical research. "In the present
study, we evaluated functional activity of the alternative pathway
of complement in schizophrenia by measuring the alternative pathway
hemolytic activity (AH50) of complement as well as hemolytic activity
of the complement C3 component (C3H50) in the blood of patients
with schizophrenia and healthy subjects. To assess the influence
of neuroleptic treatment on measured parameters, both drug-free and
medicated patients were examined," researchers in Yerevan, Armenia
report (see also Neurochemical Research).
"In addition, correlation analysis between AH50 and C3H50 has been
performed. The results of the present study clearly demonstrate
upregulation of the alternative complement cascade in schizophrenia and
activator effect of neuroleptics on complement alternative pathway,"
wrote A. Boyajyan and colleagues, Institute of Molecular Biology.
The researchers concluded: "Based upon the results obtained we
hypothesize that hyperactivation of the alternative complement pathway
in schizophrenia is stimulated by apoptotic cells."
Boyajyan and colleagues published their study in Neurochemical Research
(Alternative complement pathway in schizophrenia.
Neurochemical Research, 2010;35(6):894-8).
For additional information, contact A. Boyajyan, Institute of Molecular
Biology NAS RA, 7 Hasratyan St., 0014, Yerevan, Armenia.
Publisher contact information for the journal Neurochemical Research
is: Springer, 233 Spring Street, New York, NY 10013, USA.
From: A. Papazian
Mental Health Weekly Digest
June 14, 2010
Researchers detail in 'Alternative complement pathway in
schizophrenia,' new data in neurochemical research. "In the present
study, we evaluated functional activity of the alternative pathway
of complement in schizophrenia by measuring the alternative pathway
hemolytic activity (AH50) of complement as well as hemolytic activity
of the complement C3 component (C3H50) in the blood of patients
with schizophrenia and healthy subjects. To assess the influence
of neuroleptic treatment on measured parameters, both drug-free and
medicated patients were examined," researchers in Yerevan, Armenia
report (see also Neurochemical Research).
"In addition, correlation analysis between AH50 and C3H50 has been
performed. The results of the present study clearly demonstrate
upregulation of the alternative complement cascade in schizophrenia and
activator effect of neuroleptics on complement alternative pathway,"
wrote A. Boyajyan and colleagues, Institute of Molecular Biology.
The researchers concluded: "Based upon the results obtained we
hypothesize that hyperactivation of the alternative complement pathway
in schizophrenia is stimulated by apoptotic cells."
Boyajyan and colleagues published their study in Neurochemical Research
(Alternative complement pathway in schizophrenia.
Neurochemical Research, 2010;35(6):894-8).
For additional information, contact A. Boyajyan, Institute of Molecular
Biology NAS RA, 7 Hasratyan St., 0014, Yerevan, Armenia.
Publisher contact information for the journal Neurochemical Research
is: Springer, 233 Spring Street, New York, NY 10013, USA.
From: A. Papazian