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Chemical & Chemistry Business
March 19, 2010
ORGANIC CHEMISTRY;
Studies from National Academy of Science update current data on
organic chemistry
"The method for the synthesis of
6-imino-5-tetrahydro-1H-2-pyrrolylidenhexahydro -2,4-pyrimidinediones
is described," researchers in Yerevan, Armenia report.
"It is shown that the reaction of phosphorus trichloride,
2-pyrrolidones and 6-aminopyrimidines brings to condensation producing
6-imino-5-tetrahydro-1H-2-pyrrolylidenhe xahydro-2,4-pyrimidinediones
as intermediates for the synthesis of C-azanucleosides. The reaction
of 6-imino-1,3-dimethyl-5-tetrahydro-2-pyrrolylidenhe xahydro-2,4-pyrimidinedione
with benzoyl chloride produces 10-benzoyl-2,
4-dimethyl-6-phenyl-1,2,3,4,8,9-hexa hydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-1,3-d ione,"
wrote A. Martirosyan and colleagues, National Academy of Science.
The researchers concluded: "A method for the selective reduction of
the carbomethoxy group of methyl
5-(4-imino-1,3-dimethyl-2,6-dioxohexahydro- 5-pyrimidinyliden)-2-pyrrolidine
carboxylate by system NaBH4/1,4dioxane/CoCl2/PEG-400 is described."
Martirosyan and colleagues published their study in Tetrahedron
Letters (Synthesis of
6-imino-5-tetrahydro-1H-2-pyrrolylidenhexahydro -2,4-pyrimidinediones
as intermediates for the synthesis of C-azanucleosides. Tetrahedron
Letters, 2010;51(2):231-233).
For additional information, contact A. Martirosyan, Natl Academy
Science RA, Inst Fine Organ Chem, Azatutyan Ave 26, Yerevan 0014,
Armenia.
Publisher contact information for the journal Tetrahedron Letters is:
Pergamon-Elsevier Science Ltd., the Boulevard, Langford Lane,
Kidlington, Oxford OX5 1GB, England.
March 19, 2010
ORGANIC CHEMISTRY;
Studies from National Academy of Science update current data on
organic chemistry
"The method for the synthesis of
6-imino-5-tetrahydro-1H-2-pyrrolylidenhexahydro -2,4-pyrimidinediones
is described," researchers in Yerevan, Armenia report.
"It is shown that the reaction of phosphorus trichloride,
2-pyrrolidones and 6-aminopyrimidines brings to condensation producing
6-imino-5-tetrahydro-1H-2-pyrrolylidenhe xahydro-2,4-pyrimidinediones
as intermediates for the synthesis of C-azanucleosides. The reaction
of 6-imino-1,3-dimethyl-5-tetrahydro-2-pyrrolylidenhe xahydro-2,4-pyrimidinedione
with benzoyl chloride produces 10-benzoyl-2,
4-dimethyl-6-phenyl-1,2,3,4,8,9-hexa hydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-1,3-d ione,"
wrote A. Martirosyan and colleagues, National Academy of Science.
The researchers concluded: "A method for the selective reduction of
the carbomethoxy group of methyl
5-(4-imino-1,3-dimethyl-2,6-dioxohexahydro- 5-pyrimidinyliden)-2-pyrrolidine
carboxylate by system NaBH4/1,4dioxane/CoCl2/PEG-400 is described."
Martirosyan and colleagues published their study in Tetrahedron
Letters (Synthesis of
6-imino-5-tetrahydro-1H-2-pyrrolylidenhexahydro -2,4-pyrimidinediones
as intermediates for the synthesis of C-azanucleosides. Tetrahedron
Letters, 2010;51(2):231-233).
For additional information, contact A. Martirosyan, Natl Academy
Science RA, Inst Fine Organ Chem, Azatutyan Ave 26, Yerevan 0014,
Armenia.
Publisher contact information for the journal Tetrahedron Letters is:
Pergamon-Elsevier Science Ltd., the Boulevard, Langford Lane,
Kidlington, Oxford OX5 1GB, England.